A polygenic score for age‐at‐first‐birth predicts disinhibition
نویسندگان
چکیده
منابع مشابه
Predicting Alzheimer's disease: a polygenic hazard score.
the genetic factors that influence the development of alzheimer’s disease (ad) have been the subject of large international collaborative studies in recent years involving many thousands of patients and controls. genome wide association screens (gWas) have produced large datasets which include not only genetic linkage information but also clinical material such as age of disease onset and, in s...
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SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...
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BACKGROUND Uncertainty remains about the true extent by which alcohol consumption causes a number of health outcomes. Genetic variants, or combinations of variants built into a polygenic risk score (PGRS), can be used in an instrumental variable framework to assess causality between a phenotype and disease outcome of interest, a method known as Mendelian randomisation (MR). We aimed to identify...
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Structural brain magnetic resonance imaging (MRI) traits share part of their genetic variance with cognitive traits. Here, we use genetic association results from large meta-analytic studies of genome-wide association (GWA) for brain infarcts (BI), white matter hyperintensities, intracranial, hippocampal, and total brain volumes to estimate polygenic scores for these traits in three Scottish sa...
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A primary goal of polygenic scores, which aggregate the effects of thousands of trait-associated DNA variants discovered in genome-wide association studies (GWASs), is to estimate individual-specific genetic propensities and predict outcomes. This is typically achieved using a single polygenic score, but here we use a multi-polygenic score (MPS) approach to increase predictive power by exploiti...
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ژورنال
عنوان ژورنال: Journal of Child Psychology and Psychiatry
سال: 2020
ISSN: 0021-9630,1469-7610
DOI: 10.1111/jcpp.13224